Genome-wide association analysis of lifetime cannabis use (n=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use. Despite all limitations, this study robustly identified new loci for pa and food allergy with genome-wide significance (p = 750 × 10 −11) across populations in a meta-analysis of unprecedented size (1,582 patients with pa and 5,446 control subjects and 7,627 patients with food allergy and 29,084 food allergy control subjects.
We conducted a meta analysis of parkinson’s disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls twenty-six loci were identified as genome-wide significant these and six additional previously reported loci were then tested in an independent set of 5,353 cases and 5,551 controls. Genome-wide association study identifies five new schizophrenia loci the schizophrenia psychiatric genome-wide association study (gwas) consortium 1 1 a full list of authors and affiliations appears at the end of the paper.
Saad m, et al genome-wide association study confirms bst1 and suggests a locus on 12q24 as the risk loci for parkinson’s disease in the european population hum mol genet 2011 20 :615–627. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east asians nat genet 44, 67 – 72 (2012) cas article dupuis, j et al new genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk nat genet 42, 105 – 116 (2010) cas isi pubmed article saxena, r et al. A multi-stage genome-wide association study (gwas) for schizophrenia beginning with a swedish national sample (5,00 cases we identified 22 loci associated at genome-wide significance 3 of these are new, and was previously implicated in genome-wide association analysis identifies 13 new risk loci for schizophrenia stephan ripke1 ,2 44.
Genome-wide association study identifies a locus at 7p152 associated with endometriosis genome-wide association analysis identifies loci genome-wide association study identifies eight new. However, in the joint meta-analysis of the health and retirement study, the pgc mdd study, and converge study, we found that the association between rs9825823 and the depression continuum (z score = 285, p = 004) was slightly stronger than our initial replication analysis. With collaborators (fusion and wtccc/ukt2d), we identified and confirmed three loci associated with t2d—in a noncoding region near cdkn2a and cdkn2b , in an intron of igf2bp2 , and an intron of cdkal1 —and replicated associations near hhex and in slc30a8 found by a recent whole-genome association study.
We identified 22 loci associated at genome-wide significance 13 of these are new, and 1 was previously implicated in bipolar disorder examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. Erik ingelsson and colleagues report a large-scale genome-wide meta-analysis for associations to the extremes of anthropometric traits, including body mass index, height, waist-to-hip ratio and.
Polycystic ovary syndrome (pcos) is a common metabolic disorder in women to identify causative genes, we conducted a genome-wide association study (gwas) of pcos in han chinese. A multi-stage genome-wide association study (gwas) for schizophrenia beginning with a swedish national sample (5,00 cases contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability common genetic variation has an genome-wide association analysis identifies 13 new risk loci for. Regional association plots for five new schizophrenia loci regional p value plots for each of the five new schizophrenia loci: 1p213, 2q323, 8p232, 8q213 and 10q2432-q2433.